p27^(kip1) is a multifunctional protein that promotes cell cycle exit by blocking the activity of cyclin/cyclin-dependent kinase complexes as well as migration and motility via signaling pathways that converge on the actin and microtubule cytoskeleton. Despite the broad characterization of p27^(kip1) function in neural cells, little is known about its relevance in microglia. Here, we studied the role of p27^(kip1) in microglia using a combination of in vitro and in situ approaches. While the...